Use of Gastric Acid Reducing Agents


Routine drug based gastric protection is not used in the Christchurch Intensive Care.  There are potential risks to interfering with normal gastric acidity.  The key to gastric protection is early and successful feeding.  Individualised prophylactic treatment may be considered based on the patients past history risk factors.  These issues should be discussed with the duty intensive care specialist.

The use of intravenous omeprazole is usually reserved for the use of the treatment of severe gastrointestinal haemorrhage.


  1. Gastric Acid Reducing Agents

Ranitidine50 mg 8hrly IVI

H2-receptor blocker

Less effective acid suppression during feeding

Ill defined link with increased rates of nosocomial infection

Useful prophylactic agent


Acute Rx: 40 mg bd IVI

Established: 40 mg dly po

Proton pump inhibitor

Effective acid suppression for 24hrs

Proven efficacy in Rx of actively bleeding ulceration


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Page last reviewed: 13 May 2014